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More importantly, patients with gastroparesis or severe gastrointestinal symptoms may not tolerate dose escalation, leaving them at subtherapeutic doses

[61] Research continued, and in 1993, Michael Nauck managed to infuse GLP-1 into people with type 2 diabetes, stimulating insulin while inhibiting glucagon and bringing blood glucose to normal levels

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Weight loss plateaus represent the most common trigger

Overcoming plateaus requires recalibrating calories, increasing activity intensity, or exploring combination therapies