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Ozempic is also sometimes prescribed off-label (for a non-FDA-approved use) as a weight loss drug

J Rheumatol 18(3):452454 Del Giorno R, Skaper S, Paladini A, Varrassi G, Coaccioli S (2015) Palmitoylethanolamide in Fibromyalgia: Results from Prospective and Retrospective Observational Studies

"We believe the launch of Saxenda represents a significant contribution to the therapeutic options that are advancing obesity care

Patients should contact their healthcare provider immediately if they experience: Severe stomach pain that persists, with or without vomiting Vision changes during treatment Symptoms of low blood sugar, especially when taking other diabetes medications Signs of thyroid tumors, including neck swelling, hoarseness, or difficulty swallowing [15] Yellowing of skin or eyes, fever, or clay-colored stools [16] For patients managing both blood pressure and diabetes with Ozempic, healthcare providers may need to adjust blood pressure medications

Decision factors: Weight loss goals: Want maximum weight loss and can tolerate side effects: Tirzepatide (Zepbound) shows ~4% greater weight loss than semaglutide on average Want proven cardiovascular benefits: Semaglutide has demonstrated 20% reduction in major cardiovascular events in the SELECT trial Want to try oral option: Oral semaglutide (Rybelsus) for diabetes, though weight loss is less than injectable Side effect sensitivity: Some people tolerate one better than the other