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(iii) coordinating the protein and nucleotide synthesis (as an amino acid exchanger, for the import of serine) of murine breast tumor cells, lung tumor cells, hepatocellular carcinoma cells and liposarcoma, promoting the resistance to glutamine deprivation (in breast tumor cells and liposarcoma) and mTOR activation [227,228,229]

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The British Heart Foundation funded the trial, which also involved experts from University College London

Numerous endogenous peptides meet fundamental criteria for druggability, including defined receptors, dose-dependent physiological effects, and genetic or pharmacologic validation in preclinical models

Moleculen.Deel 25, nr