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The side effect profile of direct HGH (water retention, joint pain, insulin resistance at higher doses) is largely absent with CJC-1295/Ipamorelin at clinical doses because the physiological GH pulse is smaller and self-regulated

Tissues characterized by fast replicating cells also show reduced protein synthesis

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Additionally, withdrawal symptoms like increased appetite, binge eating, and blood sugar spikes in diabetic patients can make the transition even more challenging