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Iron chelators Deferoxamine (DFO), ciclopirox olamine (CPX), 2,2-bipyridyl and other iron chelators can directly bind free iron, maintain the balance of iron metabolism in vivo and inhibit ferroptosis induced by erastin (Fig

FIGURE 6 In animal models developing T2D, a drastic decrease in cardiolipin levels in striated muscle was identified (Figure 6, it is shown that PE improves insulin sensitivity via NOX2 (Figure 7) to promote mitochondrial remodeling resulting in improvement in glucose and fat metabolism ( 2 O 2 levels can activate p38 continuously, inducing melanocytes to premature senescence (dysfunctional) and susceptible to apoptosis ( FIGURE 7 Vitiligo patients have a reduced mitophagy process in epidermal melanocytes (Vainshtein et al., 2015)

(2010) and Tesfaye et al

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