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GLP-1-derived peptides regulate rat and human TRPV1 activation independently of GLP-1R expression To verify the potential involvement of GLP-1R in the observed inhibitory effects on TRPV1 channels, we transiently transfected rat TRPV1 into HEK293T cells

The Journal of Clinical Endocrinology & Metabolism

GLP-1 receptor agonists like semaglutide and tirzepatide work by slowing digestion and reducing appetite

Patients seeking GLP-1-based therapy should consult healthcare providers about FDA-approved options rather than relying on unproven supplements

First-trimester exposure and major malformations similarly showed no significant association, a result confirmed in a sensitivity analysis restricted to adjusted estimates