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GLP-1 is a hormone that plays a crucial role in regulating appetite and blood sugar levels
doi: 10.4049/jimmunol.165.4.2068 134 ArcaroAGregoireCBakkerTRBaldiLJordanMGoffinLet al
Certain medical conditions require additional caution during dose escalation
Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial The COR-I study found that a combination of sustained-release naltrexone and bupropion significantly reduced bodyweight in obese individuals over 56 weeks, with 48% achieving at least a 5% weight loss, while nausea was the most common side effect
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