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These investigations suggested that the peptide may impact antibody production and tumor progression, with some findings pointing to regression trends in experimental cancer models

Under a master protocol, the trials randomized 469 participants across the US, Australia, Brazil, China, Czechia, Germany, Japan, Mexico and Taiwan in a 1:1 ratio to receive tirzepatide maximum tolerated dose (MTD) 10mg or 15mg or placebo

Epidemiological data consistently show that more than 65 % of individuals with T2DM have MASLD (Younossi et al., 2024[87]), underscoring the strong metabolic link between these conditions (Targher et al., 2021[75], 2025[79]