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Although DPP-4 inhibitors do not cross the BBB under normal conditions (the pharmacokinetic feature may prevent their repurposing use in neurodegenerative diseases), the permeability of BBB is increased in neurodegenerative diseases, so molecules otherwise unable to cross BBB could enter into CNS in these conditions (103)

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Balancing expectations The gap between the widespread excitement about antioxidant therapy and the supporting data highlights the critical need for careful, evidence-based treatment strategies [41]

Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review