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While an acne relapse can be frustrating, acne usually does not return to the same level as before treatment with Accutane

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Avoid submerging the injection site in pools or hot tubs for 24 hours to minimize infection risk from the small skin puncture

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This underscores the notion that local tissue hypoxia can exacerbate inflammation and immune dysfunction, further aggravating tissue hypoxia, thereby perpetuating a vicious cycle