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IGF-1 Therapy: Insulin resistance : Overuse of IGF-1 can lead to insulin resistance, which may result in higher blood sugar levels
So it's not just a theoretical thing
Although the levels of demethylation during the pre-implantation period are significant, a portion of DNA methylation will be kept during the reprogramming after fertilization, including the imprinted genes, which represent an inheritance from the paternal environment to the offspring phenotype (Jiang et al., 2018)
Bypass surgery itself removes areas that produce necessary co-factors for absorption, which is compounded by faster gut transit time, which lessens what can be extracted from the digestive process