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Thus, GSH plays the role of a mediator in crucial cellular processes, such as cell cycle progression and programmed cell death ( The GSH itself is created from amino acids, including glutamate, L-cysteine, and glycine, through two ATP-dependent enzymatic reactions mediated by -glutamylcysteine synthetase (-ECS or also known as GSH1) and GSH synthetase (GS or also named GSH2) (Noctor et al., 2002, 2012

Moreover, central neuro-inflammation and altered inflammatory responses, together with synaptic alterations, have been shown in VPA rodent models [43,44]

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In addition, examples from other biologic therapies, such as growth factors and gene therapy, that showed early promise but failed clinical translation underscore the importance of rigorous study design, safety monitoring, and realistic expectations in peptide research