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Its the first nonpeptide small molecule GLP-1 receptor agonist with some very appealing characteristics for patients and prescribers, Ryan said during a presentation

In a Phase 2 trial for T2D, weekly semaglutide was more effective at reducing HbA1c than daily liraglutide (NCT00696657)

Standard-dose protocols generally follow the same overall concept used in FDA-approved GLP-1 treatment: start low, increase gradually, and adjust based on response and side effects

Using fatty acids to prolong the duration of the action of peptides and proteins was already a long established technique at Novo Nordisk and elsewhere and had been successfully applied to insulin (insulin detemir) (Knudsen, Lau)

Levey AS, Becker C, Inker LA