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This activation involves phosphorylation and nuclear accumulation of TAp63 in oocytes, which subsequently triggers the expression of pro-apoptotic Bcl-2 family members, including PUMA, NOXA, and Bax, initiating the apoptotic pathway (Suh et al., 2006

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Nephron segment metabolism and physiology Each nephron segment has distinct physiological characteristics, and substrate utilization and metabolic pathway activities vary substantially between nephron segments and are generally consistent with oxygen availability (Fig