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Unlike native IGF-1, this analog features a 13-amino acid N-terminal extension and an arginine substitution at position 3, conferring reduced affinity for insulin-like growth factor binding proteins (IGFBPs) and thus increased biological activity across multiple experimental models

In January, Novo Nordisk maker of both semaglutide brands could effectively lose its market exclusivity in Canada, likely opening the door to generic versions, CBC News previously reported

doi: 10.1378/chest.12-3073 65 TrompetteAGollwitzerESYadavaKSichelstielAKSprengerNNgom-BruCet al

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McGehee WG, Klotz TA, Epstein DJ, Rapaport SI