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Glycaemic dysregulation, the loss of insulin-mediated paracrine regulation of glucagon, and decrements in glucose disposal into insulin-resistant skeletal muscle contribute to circulating hyperglycaemia and perpetuate insulin resistance in MASLD [6, 15]

Initially developed for diabetes, it gained FDA approval in 2021 for chronic weight loss, thanks to successful clinical trials like the STEP program

Beyond mere weight loss, semaglutide alleviates critical health markers emphasizing risk factors for heart disease, stroke, and type 2 diabetes

Colonic L cells contain twice as much GLP-1 peptide than proximal intestine L cells (Reimann et al., 2008)

He also shares how to recover gracefully if you "blank out" on stage and simple drills and frameworks that dramatically improve spontaneity, storytelling and overall communication effectiveness