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Mitochondrial permeability disrupts the ion gradients across the inner mitochondrial membrane, resulting in mitochondrial depolarization, a loss of oxidative phosphorylation, and an increase in ROS production (Garca-Ruiz et al., 1997)

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Those with pancreatic disorders, inflammatory bowel disease, or known allergies to pork or beef products should consult their healthcare provider before using enzyme supplements

Your body produces many of these peptides naturally, but their levels decline with age

Therefore, our cohort is homogeneous and the diagnostic strategy used to build this cohort (systematical histologic review, immunohistochemistry, and molecular analysis) is relevant