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Left unaddressed, it can lead to a downward spiral of immune reactivity, neurological decline, and treatment resistance

Anti-angiogenic therapy can also reduce the prevalence of immunosuppressive cells

Its method of action could be to reduce inflammation by blocking the PI3K signaling pathway [85]

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This dual anti-inflammatory + antimicrobial action makes it particularly relevant for research models on skin pathologies where inflammation and infection coexist (Kannengiesser et al., 2017)