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Typical medications that might interact are diabetes medications like insulin or sulfonylureas, some antibiotics, blood pressure medications, and medications that slow stomach emptying, such as opioids or anticholinergics

Rescue medication was available for patients whose fasting plasma glucose exceeded the predefined limits of 15.0 mmol/L from week 8, 13.3 mmol/L from week 9 to week 20, and 11.1 mmol/L from week 21 to week 32

Sitagliptin is also a substrate of P-glycoprotein (P-gp), which may also be involved in mediating the renal elimination of sitagliptin

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