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Reduced glucose uptake precedes insulin signaling defects in adipocytes from heterozygous GLUT4 knockout mice

S.HarmsenE

Urolithins and their phase II conjugates cross the blood-brain barrier and exert a stimulus-dependent anti-inflammatory effect on microglial cells by inhibiting NF-B nuclear translocation

This biased signaling profile may reduce receptor internalization and desensitization, theoretically maintaining receptor responsiveness with chronic treatment