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However, when the intensity of heat stress exceeds the cellular tolerance threshold, the cytoprotective effects of HSPs may be overwhelmed, permitting secondary inflammatory cascades (e.g., HMGB1/TLR4-mediated NF-B activation) to dominate, thereby exacerbating hepatocyte damage [16]

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Cranial MRI in patients with FMRD may show enlarged ventricles and subarachnoid spaces [86], abnormally high signal intensity in the periventricular white matter, cerebral atrophy, delayed formation of myelin sheaths, thinning of the corpus callosum, and an abnormally small brainstem [87]