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Twenty years ago, data from Kaiser Permanente demonstrated the striking association between lower eGFR levels and higher risks of death, cardiovascular events, and hospitalization in a large community-based population kidney registry [19]

Based on SURPASS clinical trial data, peak A1C reductions generally occur between 20-24 weeks of treatment, though some patients continue to see incremental improvements up to 40 weeks

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Tirzepatide activates two: GLP-1 and GIP (glucose-dependent insulinotropic polypeptide)

These observations invite questions about the mechanisms involved, particularly because they fit into a consistent pattern of a role for Se that has been reported over several decades for a variety of RNA viruses (enteroviruses, hantaviruses, and influenza A) and viruses with an RNA stage (HIV-1 and Hepatitis B virus), as reviewed by various authors (35)