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Glucose deprivation reduces the PPP-mediated NADPH generation, making it impossible to reduce insoluble cystine imported via xCT to a more soluble cysteine, thereby inducing disulfide stress (i.e., cystine-dependent toxicity) and leading to rapid cell death [48] [Figure 3B]

87 89 Although the present review focused on the immuno pathogenesis of pulmonary diseases, the key concepts outlined here may help in interpreting the role of redox in other pathological conditions

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Following internalization, these particles undergo minimal biochemical remodeling and are efficiently incorporated into yolk spheres (66)