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Alcohol is best avoided during dose titration, as it amplifies GI side effects and affects liver function

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Dilda, Tumour Metabolism Group, Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia e-mail: [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology

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A: While an instantaneous, dramatic "lifting glow" and texturizing improvement are clearly visible after just one single application, complex structural and pigment challenges require cumulative clinical intervention