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Oxidative challenges sensitize the capsaicin receptor by covalent cysteine modification

This approach allows assessment of individual response and minimizes the impact of any unexpected sensitivity

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Proteomics 9, 23432354 (2009)

Even if one has full knowledge of the associated reaction network along with the binding constants and rate constants, it is not so easy to grasp how and what type of cell physiology emerges from the network and which bio-chemical steps are the key factors responsible for the resulting process [52, 72]