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The short, practical answer is: sometimes, for modest goals - but not always for large, medically supervised weight loss
Metformin and a Decreased Incidence of Cancer Diabetes has been associated with an enhanced risk for the development of various cancers (236)
They have been reported to reduce symptoms of angina and peripheral vascular disease, and they may improve outcomes for people with serious heart conditions, such as coronary heart disease or heart failure [5]
10.1056/NEJMoa1705342 185
STEP 5 confirmed 15.2% at 2 years SELECT (CV outcomes): 17,604 patients, 20% MACE reduction Evidence level: Very high -- extensive multi-program evidence with cardiovascular outcomes
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