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Patients in our Las Vegas weight loss program using tirzepatide typically notice reduced appetite and changes in food preference within the first 1-2 weeks of therapy

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This finding led us to investigate whether improving CFTR function using drugs prescribed for cystic fibrosis patients, such as the CFTR potentiator VX-770 (Ivacaftor) 92 and the second-generation CFTR corrector VX-445 (Elexacaftor) 93,94,95 , often used in combination with the first-generation CFTR corrector Tezacaftor, could produce similar effects

Supergut spoke to leading experts in the field, who lauded these drugs transformative effects as well as unbelievable promise in weight-loss trials

Comparative selectivity studies against less-selective GHS compounds (GHRP-2, GHRP-6, hexarelin) to characterize receptor-binding profiles and downstream signalling specificity