It is normally conjugated by glutathione (GSH), but when taken in excess, the body's glutathione reserves are not sufficient to deactivate the toxic NAPQI
However, keeping in mind that methylation of homocysteine is an essential pathway to the formation of Met, it seems likely that GSH metabolites influence the enzymes involved in Met synthesis
However, only a few are now undergoing clinical testing
Ipamorelin, the first selective growth hormone secretagogue
If you're on a 1ml weekly protocol and seeing no measurable change after six weeks, the problem is almost never 'too low a dose.' It's either formulation quality (underdosed methionine or choline), dietary interference (you're in maintenance calories, not deficit), or liver saturation (you're already consuming high dietary methionine and adding more doesn't shift the pathway further)