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CrAT can perform reactions in both directions, therefore its activity depends on the acetyl-CoA/free CoA ratio and the availability of carnitine

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Functional enrichment analysis of cluster genes To understand the biological function of the meta-modules, we performed GO term enrichment analysis using both the topGO (v2.50.0) and the clusterProfiler (v 4.6.2) R packages 41,42

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Treatment should be initiated under medical supervision to establish the underlying cause and appropriate dosing schedule