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Because semaglutide slows down how quickly food leaves your stomach (gastric emptying), it can affect how some oral drugs are absorbed by your body

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Fibers, flakes, crystals, or any solid matter floating in the solution indicates that the formulation has destabilized or that foreign material has entered the vial

This occurs when food empties too slowly from the stomach into the intestines, resulting in severe nausea and vomiting

Time-of-day physiology shows minimal differences in semaglutide absorption between morning and evening injections, so circadian timing is less critical than simple consistency