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Finally, vitamin B12 is crucial for the biochemistry of the nervous system, participating in DNA synthesis, methionine synthesis, methylation reactions, myelin synthesis, and neurotransmitter production (, , , , , , )

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The location of the PSPH gene on chromosome 7p11.2 is in a region of chromosome 7 that is deleted in Williams-Beuren syndrome, WBS (also called Williams syndrome, WS)