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She found that in her case, a lack of estrogen combined with stress on her body was causing an increase in inflammation and belly fat, and difficulty losing weight

Its main functions are stimulation of insulin secretion in a glucose dependent manner and contribution to fat metabolism in adipocytes

This dual-hormone activity (GIP + GLP-1) is one reason tirzepatide may lead to stronger appetite control and weight-loss effects than GLP-1-only medications like semaglutide

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Metabolic surgery versus conventional medical therapy in patients with type 2 diabetes: 10-year follow-up of an open-label, single-centre, randomised controlled trial