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for example, in sepsis or ischemia-reperfusion injuries, impaired GPx4 allows ferroptosis to contribute to tissue damage, worsening outcomes

Anal Chem 82:26962702 Zhang WB, Li PL, Geng QQ, Duan YH, Guo MC, Cao YS (2014) Simultaneous determination of glutathione, cysteine, homocysteine, and cysteinylglycine in biological fluids by ion-pairing high-performance liquid chromatography coupled with precolumn derivatization

Future GLP-2 trials in IBD should stratify patients by disease phenotype (mucosal UC, inflammatory CD, stricturing CD) and incorporate serial cross-sectional imaging to monitor for stricture progression, given the mechanistic link between GLP-2R signaling through subepithelial myofibroblasts and intestinal fibrogenesis

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The role of GCG neuronal regulation in energy homeostasis circuitry remains largely unclear