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AD is characterized by the accumulation and aggregation of misfolded proteins in brain, the sustained activation of the UPR mediated by the misfold proteins initiates or mediates neurodegeneration ( Oxidative Stress Oxidative stress is a condition in which the production of reactive oxygen species (ROS) exceeds the detoxifying power of antioxidants, it contributes significantly to the pathogenesis and progression of MAFLD ( Intervention Strategies to Reduce TMAO Concentrations Changing Dietary Habits TMAO is mainly derived from the gut, and its concentration depends on the type and amount of dietary nutrients consumed (Figure 2)

Daily supplements such as vitamin D, calcium and omega-3 fatty acids have strong evidence for supporting bone, cardiovascular and general health when deficiencies exist

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Stevia is known for its highly sweet leaves and has achieved worldwide reputation as a natural, low-calorie sweetener