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The efficacy of a second-generation derivative, omaveloxolone (RTA408), has recently been assessed in a preclinical model for diabetic chronic non-healing wounds [277] and, interestingly, omaveloxolone is now being tested in phase-II clinical trial for the Friedreichs ataxia (FRDA), a neurodegenerative condition in which NRF2 activation is suppressed [278, 279]

or (4) placebo in a double-blind parallel design before being exposed to the Trier Social Stress Test which involved delivering a speech and mathematical cognitive test in front of an unresponsive human panel

Probiotics support a healthy gut microbiome, which can stave off inflammation

Clinical course of three Saudi children with a severe phenotype