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Compound 968 can inhibit Rho GTPase-induced carcinogenic transformation by targeting glutaminase activity in some transformed and cancer cells with Rho GTPase/NF-B-dependent GLS activation (Wang et al., 2010

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Variants in FTO , GLP1R (the receptor these compounds target), MC4R (central to satiety and energy balance), and TCF7L2 (tied to glucose homeostasis and GLP-1 secretion) map that baseline

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