Two studies investigated animal models of comorbid depression and epilepsy 159,161 : one showed that exendin-4 led to an increase in frequency of absence seizures as well as depressogenic and anxiogenic responses 159 , while the other saw a decrease of depression-like behavior for liraglutide irrespective of concurrent use of the antiepileptic levetiracetam 161
Specifically, GLP-1 activity has been observed in areas like 8: The hypothalamus, which regulates appetite The brainstem, which connects gut signals to the brain The limbic system, including the nucleus accumbens and ventral tegmental area, which are involved in reward and cravings Through these pathways, GLP-1 medications may: Reduce food cravings and food noise Change how rewarding certain foods feel Lower motivation to seek out highly palatable foods There is also emerging interest in whether these effects extend beyond food
And so our next step was to try and get a live lizard and obviously these are difficult to obtain, you cant walk into a pet store in Toronto and order these things. Murphy then contacted the Utah Zoo, known for its expertise in lizard breeding, asking about the possibility of getting one for research
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