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Activated microglia increase expression of proinflammatory cytokines including IL-1, IL-6, TNF-, and Ccl2, which stimulate microglial proliferation 53,54,55,56,57

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The need for diagnosis, treatment and prevention of AITD is also due to the need to prevent concomitant diseases, including disorders of the cardiovascular system, hypercholesterolemia, atrial fibrillation, encephalopathy, others autoimmune diseases ( Cellular and humoral immunity in the pathogenesis of AITD In addition to genetic, cellular and humoral immune mechanisms, loss of immune tolerance to thyroid autoantigens is the basis for the development of AITD