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This bypasses the "hepatic filter" and avoids the first-pass metabolism that normally occurs in the liver, which deactivates a large portion of the glutathione molecule, making it less functional and effective

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24 Interestingly, ascorbate spares glutathione, and has been shown to increase glutathione concentrations in human patients, 25,26 even in those with hereditary defects in glutathione synthesis

Inflammation is associated with increased glutamate, whereas the antioxidant glutathione may protect against inflammation-induced oxidative stress