Explorations in statistics: the analysis of ratios and normalized data
The first drug was really coming out at that time called Gleevec, which treated CML (chronic myeloid leukemia.) I treated patients before that era who had to have a bone marrow transplant or they were basically going to die of CML
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Notably, the high levels of heterogeneity in the studies analyzed as well as other measures such as variability in study populations, interventions and methodologies, could have affected the reliability of the results obtained
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