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Int J Mol Sci 21:1857 Acknowledgements This work was financially supported by Jiangsu Provincial Science and Technology Think Tank Program Project (JSKX0125070), the Natural Science Fund for Colleges and Universities in Jiangsu Province of China (20KJA180004), the Natural Science Foundation of Huaiyin Institute of Technology (23HGZ013), the National College Student Innovation and Entrepreneurship Training Program (202511049026) and the Talent Introduction Research Project of Huaiyin Institute of Technology (Z301B16534)