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Aoyagi T, Aoyama T, Kojima F, Matsuda N, Maruyama M, Hamada M et al

Inhibitor 968 has been demonstrated to induce cell cycle arrest in G1 phase and to increase cellular ROS production, promote cellular stress and induce apoptosis in cancer cells, and inhibit the AKT/mTOR/S6 signalling pathway

Tsuji-Naito et al 27 demonstrated that DHLHZn (sodium zinc dihydrolipoyl histidinate, compound of Zn2+/dyhydrolipoic acid derivative complex, which was developed for cosmetic/medical use) serves as a potentially effective skin-lightening agent, an effectiveness that is based on the compounds covalent scavenging of DOPAquinone, resulting in depigmentation

Subsequent biochemical and cytochemical studies demonstrated that HGF nitration is maximal in a physiological pH range at Y198 and Y250, characterized by their respective locations at the c-met binding sites of the K1 and K2 domains of the HGF -chain