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Systemic involvement was diagnosed in view of the grey-bluish macules in hollow organs such as the stomach, small and large intestines

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TML undergoes a series of enzymatic reactions, including -N-trimethyl-lysine hydroxylase (HTMLA), -butyryl transferase (BBOX), etc., and is finally converted into L-carnitine

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The complete list with gene symbols, compound names, and IDs (Ensembl protein IDs and Compound IDs, resp.,) is additionally provided (see Supporting Information Tables S1, S2, and S3 available online at For elucidating the topological network properties, Cytoscape ( an open source platform for complex network analysis and visualization, was used [20]