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Its selectivity makes it particularly relevant in experimental models focused on controlled receptor activation and signal precision

Real-Time PCR Total RNA of kidney tissue was extracted by TRIzol method

Inhibition of fibroblast growth factor receptor 4 significantly reduces glutathione synthesis, leading to excessive ROS production and unstable iron pool accumulation, which triggers ferroptosis to overcome drug resistance of HER2-positive breast cancer (144)

It was not a major reason for discontinuation in the trial, but it represents a side effect category that tirzepatide users do not encounter