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The binding of solTNF to the cognate receptor results in the procurement of the TNF adaptor protein (TNF receptor-associated death domain -TRADD), which leads to the binding of other cytosolic adaptor proteins like FAS-associated death domain (FADD), TNF receptor-associated factor 2 (TRAF2), and receptor-interacting protein (RIP)

10.1007/s00394-021-02543-x 65 Carrasco-QuerolN.Cabricano-CangaL.Bueno HernndezN.GonalvesA

This comparison establishes whether multi-receptor engagement provides advantages over single-receptor activation in specific research contexts