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This isoform carries a 10-fold lower affinity for pituitary activin compared to FS-288, and by avoiding cell surface binding through heparan sulphate proteoglycans, it circulates systemically making it the preferred isoform for muscle-targeted research applications where minimising reproductive axis interference is a priority
2012 Feb;42(1):71-8
There is no evidence supporting safe use in women
Zaenglein, (2016) Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol
Also, prolonged NSW ( 10 years) correlated with hypomethylation in NR1D1, and hypermethylation of CSNK1E, a kinase regulating PER proteins downstream of CLOCK 215
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