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Subjects homozygous for this mutation ( MTHFR 677TT genotype) exhibit reduced MTHFR activity and increased risk for a wide variety of cancers (41-43), but the evidence of an association between this polymorphism and cancer is inconsistent, with some reports suggesting a reduction in colorectal cancer risk with the T allele (44)

GSH and apoptosis Apoptosis is the canonical form of regulated cell death, characterized by cell shrinkage, chromatin condensation, nuclear fragmentation, and the formation of membrane-enclosed apoptotic bodies 31

Gastroprotective effect of mangiferin, a xanthonoid from Mangifera indica, against gastric injury induced by ethanol and indomethacin in rodents

Growing evidences indicate that the increased production of reactive oxygen species and oxidative stress, a condition occurring when this balance is disrupted by excessive production of reactive oxygen species and/or by inadequate antioxidant defenses, in the brain are among the causative mechanisms of cerebral tissue damage in both ischemic and hemorrhagic strokes

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