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Those already treated privately with weekly 2.4mg Wegovy injections can swap straight to 25mg tablets once daily, if suitable, the MHRA said

This rigid protocol creates scheduling challenges for many patients

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The loss of insulin sensitivity of hippocampal CA1 pyramidal neurons can subsequently cause long-term Ca 2+ -dependent afterhyperpolarizations (AHPs), which can produce significant cognitive and memory impairment in the short term and throughout life, contributing to depression (122, 123)

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