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Parkin functions as an E3 ubiquitin ligase, playing a neuroprotective role in maintaining mitochondrial metabolism and regulating the ubiquitinproteasome system [94]

APOB (apolipoprotein B) plays a crucial role in lipid transport by serving as an essential structural component of lipoprotein particles, such as chylomicrons, to facilitate the absorption and transport of dietary lipids 73

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In the IBD gut, cell pyroptosis is caused by inflammasome activation (e.g., NLRP3), essential for innate immune reactions, and is vital for gut-brain balance and gut microbiota maintenance (227, 228)