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Rescuing IOC with amlodipine in the animal model As an L-type Ca 2+ channel blocker, amlodipine can reduce the entry of non-transferrin-bound iron (Fe 2+ ) via L-type Ca 2+ channels, resulting in lower levels of cardiac iron and reduced oxidative stress in cardiac tissue

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[DOI] [PMC free article] [PubMed] [Google Scholar] 37.Tu Y., Sun W., Wan Y.-G., Che X.-Y., Pu H.-P., Yin X.-J., Chen H.-L., Meng X.-J., Huang Y.-R., Shi X.-M

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A significant decrease in blood pressure, oxidative stress and apoptosis has also been seen in trophoblasts derived from placentas of PE rats treated with RESV [58], as well as a significant improvement in placental epithelial characteristics [59]